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KMID : 0617819940040010053
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Journal of Wonkwang Oriental Medicine
1994 Volume.4 No. 1 p.53 ~ p.83
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Effects of Ondamtang Water Extract on the Cardiovascular System in Rabbits
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成彊慶/Sung, Gang-Kyung
文炳淳/朴暎淳/金世吉/Moon, Byung-Soon/Park, Yong-Soon/Kim, Seh-Gil
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Abstract
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The present experiments were designed to investigate the effects of Ondamtang water extract(Ondamtang) on the blood circulation, bile acid secretion and mental tension in normal and hyperlipidemia induced rabbits. In order to control the precise chemical and physical conditions, the experimental rabbits were supplied with calorie limited food, and the hyperlipidemia rabbits were induced by oral administration of cholesterol(500㎎/㎏) for 3 weeks.
The results obtained were summerized as follows:
1. Ondamtang increased the bile secretion and serum bile acid level in rabbits.
2. Bile solution decreased the blood pressure after injection through the ear vien in rabbits.
3. The blood pressure was decreased after injecting Ondamtang through the ear vein. And it was also decreased after oral administration of Ondamtang for 5 days.
4. The decrease of blood pressure was not dependant on the autonomic nervous system.
5. Ondamtang activated the Mg^2+ -Ca^2+ -ATPase activity of cardiac indoplasmic reticulum, and thus inhibited the cardiac muscle contraction.
6. Ondamtang stimulated the dilatation of the peripheral blood vessel.
7. Ondamtang decreased the serum creatinine level by stimulating the renal filtration and thus it increased the kidney function in hypelipidemia rabbits.
8. Ondamtang decreased the arteriosclerosis index by effecting the metabolism of cholesterol and lipid in hypdrlipidemia induced rabbits.
9. Ondamtang inhibited the Na^+ -K^+ -ATPase activity of the cerebral cortex, and decreased the sensitivity of the electrical shock.
According to the above results, Ondamtang improved blood circulation by dilatation the capillary lumen and decreasing in blood viscosity, promoted bile acid secretion, inhibited the nerve transmission, and relieved the mental tension.
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